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English words and Examples of Usage
use "mediates" in a sentence
The apical sodium/bile acid co-transporter (asbt) mediates the active uptake of conjugated bile acids in the ileum [ 5 6 ] .
thaliana , CSN was shown to be required for the efficient nuclear accumulation of the putative RING-type ubiquitin ligase COP1 [ 24], which mediates ubiquitin-dependent degradation of the photomorphogenic transcription factor HY5 [ 25].
The ubiquitylation reaction involves a minimum of three enzymes: An E1, which mediates the ATP-dependent activation of ubiquitin, and an E2, or ubiquitin conjugating enzyme (UBC), which, together with an E3 ubiquitin ligase, transfers ubiquitin to the target protein.
Studies in budding yeast identified SCF Cdc4p, an E3 ubiquitin ligase complex that mediates the ubiquitylation of the CDK inhibitor Sic1p [ 3 4 ] .
Whether this unusual heterooligomeric SCF Pop1p-Pop2pcomplex exists in vivo and whether it mediates Rum1p ubiquitylation, remained unproven, as not all fission yeast SCF core subunits were identified.
A heterooligomeric SCF Pop1p-Pop2pcomplex mediates polyubiquitylation of phosphorylated Rum1p.
For example, products of Ste18, Ste4, Cdc42, Cdc24, Far1, Bem1, Ste20, Ste5, and other proteins are thought to constitute a complex that has numerous interactions among components, and that mediates many different cellular processes [ 14 28 ] .
Electron microscopy of the SPARC-null dermal fibroblasts at wound sites should not only confirm the role of SPARC in cell motility but also reveal how SPARC mediates cell-ECM and cell-cell interactions to promote cell motility.
Indeed, we previously reported that RGS3 bound Gq?
[ 9 ] , the G protein subunit that mediates GnRH receptor signaling [ 38 ] .
Each contains an SH3 domain, a SAM (sterile alpha motif) domain, a proline-rich region, which mediates binding to the second SH3 domain of Bem1, and a PH domain [ 1 2 3 ] .
In addition, Boi1-PH contains the region of Boi1 that displays the two-hybrid interaction with Cdc42, raising the possibility that the PH domain, itself, mediates or regulates the association with Cdc42 [ 1 ] .
In addition, the SH3 domain of Cas mediates an interaction with FAK, C3G, CMS, and the zinc finger containing protein CIZ, while nephrocystin interacts with Cas via its SH3 domain and proline rich sequences in Cas [ 24 25 26 27 28 29 30 ] .
The ubiquitin transfer reaction involves three enzymes: E1, which mediates the ATP-dependent activation of ubiquitin, and E2, or ubiquitin conjugating enzyme (UBC), which, together with an E3 ubiquitin ligase, transfers ubiquitin to the target protein.
Biochemical studies identified SCF SKP2, an E3 that mediates p27 ubiquitylation in vitro [ 20 21 ] .
SKP2 contains a so-called F-box, which mediates binding to SKP1, and C-terminal leucine-rich repeats that recognize p27.
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