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Sentences for "antagonist"
Wouldn't having Gingrich as his main antagonist have helped Clinton?
Immediately after the opinion was released, Ed Black, a Microsoft antagonist who heads the Computer and Communications Industry Association, told reporters in front of the courthouse: "The behavior they [Microsoft] are accused of, which the judge seems to be finding in fact that they did, is not behavior off to the side of their business.
" One antagonist says Putin was dubbed "Stasi" (the name of the former East German secret service) for wielding behind-the-scenes power.
Even my antagonist in "The Book Club," Richard A.
Corridos (ballads) from the Texas-Mexican border originating from the late 1800s until the turn of the century narrate episodes of border conflict in which the antagonist is often a member of the dreaded rinches.
The National Ambulatory Medical Care Survey reported that the number of people on any type of peripheral alpha-1 antagonist in 1995 was approximately 6 to 7% of those with hypertension [ 5 ] .
[ 3H]granisetron is a potent antagonist of the wt 5-HT 3 R (K d = 0.
This difference in binding site interactions of the antagonist d -tc and the agonists 5-HT and m CPBG could be the result of a slightly different positioning of d -tc in the binding site.
Lerisetron is a potent 5-HT 3 R antagonist first synthesized by Orales et.
Lerisetron is the only antagonist tested that shares a binding site interaction in this region with agonists.
Since the role of a competitive antagonist is simply to block the binding of agonists and prevent channel opening, the specific amino acids that interact with the ligand can vary for different antagonists.
For example construction of a "hybrid" ligand that combines the interactions of [ 3H]granisetron with those of d -tc, 5-HT or m CPBG could produce an antagonist with increased affinity due to the additional binding energy of these interactions and a greater specificity since it would utilize more structural features of the binding site.
Hibert et al proposed an early model for the antagonist pharmacophore of the 5-HT 3 R [ 18 ] .
These data correspond well with previously reported data for this compound [ 22 ] and verify the competitive antagonist action of lerisetron.
Analog 1 is far less similar to lerisetron and more similar to the 5-HT 3 R antagonist granisetron.
The IC 50 value was calculated as the concentration of antagonist inhibiting the 5-HT evoked response by 50%.
Whether BMP-5 function can be antagonized by noggin or follistatin has not been previously reported, but our results suggest that simultaneous addition of either antagonist with BMP-5 significantly inhibits the dendrite-promoting activity of BMP-5 in a concentration-dependent manner.
As our results show phytoestrogens are more prevalent and have greater affinity for certain brain structures and areas, therefore, phytoestrogens may act both as agonist and antagonist in a site-specific manner or in other words as natural SERM-type molecules [ 35 38 39 40 41 42 ] .
These would be drugs that act as an agonist at one receptor and as an antagonist or partial agonist at another receptor type.
While both these ligands bind with high affinities (less than 1 nM) to µ opioid receptors, WIN 44,441 acts as an antagonist at µ opioid receptors and xorphanol is a very weak agonist at µ opioid receptor (Gharagozlou et al.
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