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Sentences for "anticoagulant"
Although circulating MP of various cellular origin in patient with sepsis were reported to be procoagulant through multiple mechanisms [ 8 9 ] , in healthy individuals they may have an anticoagulant function by promoting the generation of low amounts of thrombin that activate protein C [ 2 ] .
The molecular basis of inherited thrombophilia now includes mutations in the genes for Factor V, prothrombin, methylenetetrahydrofolate reductase (MTHFR) and several others [ 15 ] , in addition to those encoding proteins such as antithrombin, protein C, and protein S whose role in the homeostasis between procoagulant and anticoagulant activities in the circulation is well established.
Further investigation revealed an autosomal-dominant inherited defect in the anticoagulant function of factor V resulting in resistance to the anticoagulant action of activated protein C (APC) [ 18].
The whole blood was collected in red-top vacutainer tubes (no anticoagulant or serum separator).
Among male patients reported to date who have hypogonadism and RAD are individuals with systemic lupus erythematosus (SLE) [ 4, 5, 6, 7], lupus anticoagulant and antiphospholipid syndrome associated [ 8], scleroderma [ 9, 10, 11, 12], rheumatoid arthritis (RA) [ 13], ankylosing spondylitis (AS) [ 14, 15, 16], and polymyositis [ 17], while Turner's syndrome has been associated with autoimmune thyroiditis [ 3], juvenile rheumatoid arthritis (JRA) [ 18], and juvenile-onset inflammatory bowel disease [ 19].
These data suggest that, although use of drotrecogin alfa (activated) reduces sepsis-induced mortality, its anticoagulant effects may increase the risk for life-threatening bleeding complications.
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