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Sentences for "antifungal"
Thus, it has been suggested that RNA triphosphatase is a promising target for antifungal drug discovery [ 2 ] .
Based on these findings, and the presence of a Cet1 homolog in the Apergillus fumigatus proteome, we conclude that RNA triphosphatase is a valid target for antifungal drug development.
The imidazoles, which are antifungal agents that inhibit cytochrome P 450 , are relatively non-selective and are known to block voltage-gated Ca 2+channels and receptor-activated Ca 2+influx through so-called store-operated channels (SOCs) [ 29 ] , but their mechanism of action in this regard remains unknown.
The piperamides (cepharadione A and B) from Piper auritum possess antifungal and anaesthetic properties [ 61 ] .
Six of the eight characterized genes within the top 20 genes in this cluster encode proteins that are localized to or function in relation to the cell wall, including those involved in bud growth and cell separation ( AXL2, CIS3, SIM1 ), cell-wall proteins induced by antifungal drugs ( SVS1, PRY2, PRY4, CRH1, TOS6 ), a putative cell-wall sensor ( WSC2 ), and a Golgi mannose transporter required for glycosylation of cell-wall proteins ( VRG4 ) (see [ 21] for references).
All cases of chronic or disseminated disease call for antifungal therapy, but the choice of drugs, route, and duration of therapy is highly dependent on the form of the disease, the severity and site(s) of infection, and the immune status of the patient.
There are only two classes of antifungal therapy routinely used for treatment of coccidioidomycosis.
Specifically, an analog of the antifungal pentamidine has been optimized as a trypanocidal agent and is in clinical trials in Africa.
In recent years, however, an increasing number of physicians are prescribing azole antifungals in cases of primary disease, both because drugs like fluconazole have a good safety record, and because there is a perception that treatment may prevent progression to more serious forms of the disease.
With funding from the Bill and Melinda Gates Foundation, more than a dozen faculty and scientists from six research institutions (see Box 1) are working in collaboration with Immtech International to manage the “cross-over” development of antifungals produced by Immtech as potential drugs for African trypanosomiasis, also known as African sleeping sickness.
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