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English words and Examples of Usage

Example Sentences for "antihypertensive"

The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a randomized, two-component clinical trial sponsored by the National Heart, Lung, and Blood Institute (NHLBI).

A double-blind, active-controlled hypertension component is designed to compare the rate of fatal coronary heart disease (CHD) or nonfatal myocardial infarction (MI) (the primary endpoint) in high-risk hypertensive participants, aged 55 years or older, between those randomized to treatment initiated with a diuretic (chlorthalidone) and treatment initiated with each of three alternative antihypertensive drugs: a calcium-channel blocker (amlodipine), an angiotensin-converting enzyme (ACE)-inhibitor (lisinopril), or an alpha-adrenergic blocker (doxazosin).

Following independent reviews by the Data and Safety Monitoring Board (DSMB) on January 6, 2000, and by an Ad Hoc Committee on January 21, 2000, the Director of the National Heart, Lung, and Blood Institute accepted a recommendation to discontinue the doxazosin treatment arm of the antihypertensive trial.

Chlorthalidone and doxazosin participants with hospitalized or fatal HF had similar pre-trial antihypertensive treatment durations.

Medical Management Table 2presents post-event pharmacologic treatment of participants with HF and antihypertensive treatment of participants without HF.

txt Background With the publication of the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT), the role of peripheral alpha-1 antagonists in the treatment of hypertension has become controversial.

The VA Cooperative Study on Antihypertensive agents was a double-blind, randomized controlled trial comparing atenolol, captopril, clonidine, diltiazem, hydrochlorothiazide, prazosin, and placebo for differences in antihypertensive efficacy in 1,105 men who had mild diastolic hypertension [ 10 ] .

Comparing data from other studies suggests the possibility that the beneficial effects of peripheral alpha-1 antagonists for lowering blood pressure may be nullified by a negative effect, or that other antihypertensives have positive actions beyond their antihypertensive effects.

The literature suggests several mechanisms by which peripheral alpha-1 antagonists in general and doxazosin in particular might prove inferior to other types of antihypertensive therapy.

None has utilized electronic medication monitors to study this area involving antihypertensive medications.

We consequently undertook this present study among several hundred individuals who were receiving antihypertensive therapy in order to explore which demographic, behavioral, and clinical characteristics might be associated with over-reporting of adherence.

Briefly, the study was conducted at Harvard Pilgrim Health Care (HPHC), a managed care organization located in New England, among members who were receiving antihypertensive medication from 1992 to 1994.

Electronic monitoring vials were dispensed with a fresh supply of antihypertensive medication upon enrollment in the study.

Participants were instructed by pharmacists to keep all their medication in the monitoring vial, use no other source of antihypertensive medication, and to remove only one dose at a time from the monitoring vial.

Comparing data from other studies suggests the possibility that the beneficial effects of peripheral alpha-1 antagonists for lowering blood pressure may be nullified by a negative effect, or that other antihypertensives have positive actions beyond their antihypertensive effects.



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