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Sentences for "antimitotic"
In some experiments this antimitotic was not added to cultures but rather endogenous non-neuronal cells were allowed to proliferate.
This view is supported by gradual diminution of promitotic cyclin E and an increase of antimitotic p27 proteins during trophoblast culture (Fig.
Studies with paclitaxel or other antimitotic agents, such as colchicine or estramustine, indicate that drug interactions with tubulin isotypes differ [ 21 22 23 24 25 ] and might contribute to cell resistance to antimitotics [ 26 27 28 29 30 31 ] .
However, one group of antimitotic agents, the vinca alkaloids, was shown to bind with similar affinity to all tubulin isotypes [ 12 ] , suggesting that alterations in drug binding affinity is unlikely to be the cause of drug resistance.
Nevertheless, we cannot exclude the possibility that changes in the distribution of tubulin isotypes in normal and tumor breast tissue, in conjunction with other molecular factors, might still be relevant to disease progression and cellular response to antimitotic drugs.
This work fulfills their suggestion to quantify changes in tubulin isotype levels with the appropriate antibodies, and establishes a sensitive and accurate assay to complement mRNA assays and studies of the response of cultured cells to antimitotic drugs.
Whether tubulin isotype levels might determine cellular responses to antimitotic agents remains controversial.
It was demonstrated that one group of antimitotic agents, vinca alkaloids, bind with similar affinity to all ß-tubulin isotypes [ 12 ] , thus suggesting for therapy with vinorelbine, vinblas-tine, or vincristine that tubulin isotype levels are incidental for efficacy.
The alternative hypothesis, derived from the work of Cabral and colleagues, is that rather than the tubulin isotype levels, the amount of polymerized tubulin is the critical factor that regulates response to antimitotic drugs.
The ß-tubulin isotype levels in normal and tumor tissue are not significantly different and are therefore unlikely to contribute to differential responses of tumors to antimitotic agents.
Introduction Common agents currently used in treating metastatic breast cancer are the antimitotics paclitaxel and docetaxel [ 1 2 ] .
Mammalian microtubules are formed from a mixture of ?
-tubulin and ß-tubulin isotype classes [ 11 15 16 ] , and the antimitotics used in chemotherapy interact primarily with ß-tubulin.
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