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Sentences for "antituberculous-antitumor"
13% patients had a history of diagnosis of tuberculosis, and 12% gave a history of previous treatment with antituberculous drugs.
In these two studies, designed to look at the relationship of ALDH1A1 activity to antitumor drug resistance, the levels of ALDH1A1 were low in HL-60 compared to other cell types, corresponding to the sensitivity of HL-60 cells to oxazaphosphorines.
Several mechanisms of action may account for the antitumor activities of d-limonene [ 23 24 25 ] .
CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] .
Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] .
To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .
To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized ß-lactam prodrugs.
This selective activation of prodrug 2 at the tumor site will lead to enhanced antitumor therapeutic efficacy.
If rapamycin and its analogs are to be developed as useful antitumor agents, it will be important to determine how p27 Kip1levels affect responsiveness to these compounds.
The observed antitumor activity of this sE dietary supplementation was an unexpected experimental result as sE was not previously reported to have antitumor activity although vitamin E may give modest protection against the risk of breast cancer [ 5 ] .
Based on the observed antitumor activity of high dose sE in the diet, it became important to investigate if the sE supplement, when fed at such a high dose, was associated with the modification of the fatty acid composition of mitochondrial and microsomal membranes and if the sE was acting as an antioxidant or possibly a prooxidant in tumor and in host tissues.
Given that such a high dose of sE has antitumor activity, it also became important to look for possible side-effects in host tissues prior to further preclinical trials.
Specifically, this experiment was originally designed to test the hypothesis that DOX, a prooxidative cancer chemotherapeutic drug, inhibits tumor growth by increasing lipid peroxidation products in the tumor to cytostatic or cytotoxic levels and that suppression of lipid peroxidation by sE would suppress the antitumor effects of DOX [ 11 12 ] .
Other possible antitumor actions include: induction of apoptosis, interference with hormone production, modulation of cellular signaling and gene transcription, and induction of differentiation [ 4 21 22 23 24 ] .
Clearly, more research is needed on the antitumor effects of sE but caution is advised that sE may also have side-effects in the heart.
Further, the angiostatic and antitumoral activities of the human endostatin has been demonstrated in different rat models [ 26 27 28 ] .
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