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English words and Examples of Usage

Example Sentences for "antiviral"

The credit appears to go to aggressive use of the antiviral drug AZT.

In any case, the HIV +state is replete with antagonistic complexities of antiviral effects of IFN-?

and TNF-?

on one hand, and their inflammatory effects on the other.

Pediatric RSV disease claims about a million lives annually, and no reliable antiviral or vaccine currently exists [ 27 28 ] .

The anti-F dsRNA also had no effect on P protein levels, suggesting that such dsRNAs do not activate a general antiviral response that might abrogate all viral mRNA translation.

Similar RT-PCR of viral genomic RNA, viral P mRNA, or cellular actin mRNA revealed essentially no reduction, suggesting that the dsRNA did not activate a general antiviral response, and did not directly target genomic RNA.

These results provide the first direct evidence that the 21-nt long double-stranded siRNAs fail to trigger interferon response in mammalian cells, and hence, can be used as specific antiviral agents.

While the resistance of the viral genomic RNA to dsRNA has important ramifications for antiviral therapy, it is also clear that the dsRNA approach cannot be used against cis -acting NNR viral genomic sequences such as the intergenic regions, for which the cDNA-based approach will continue to be the method of choice [ 16 ] .

It is obvious that a creative combination of the two techniques will lead to exciting possibilities in the reverse genetics of RNA viruses and in the antiviral regimen.

Other examples include antibody resistant mutants and escape mutants when the antiviral drug targets entry, such as rimantidine and amantidine-resistant influenza strains or WIN compound-resistant picornaviruses [ 61 ] .

Physicians also rated side effects of antiviral therapy for hepatitis C on a visual analog scale.

Finally, participating physicians provided their threshold for recommending antiviral therapy.

This test also was used to evaluate for an association between preference values for hepatitis C health states, ratings of side effects of antiviral therapy, and treatment threshold.

The median preference value for life with the side effects of antiviral therapy was 47% (interquartile range 23%-55%).

Only 13% of participating physicians would accept the 30% response rate offered by current antiviral therapy for patients with HCV genotype 1 disease (Figure 2).

Discussion In the current study, we developed and evaluated descriptions of hepatitis C health states and side effects of antiviral therapy.



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