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Sentences for "apoptotic"
Consistent with the induction of apoptotic cell death, GCDCA, but not TCA, preferentially induced the activation of the initiator caspase 8 in McNtcp.
Moreover, GCDCA was demonstrated to activate both initiator and effector caspases, and that the apoptotic response can be blocked by Crm A, a caspase 8 inhibitor [ 25 ] .
Both taurine- and glycine-conjugated bile acids induce apoptotic cell death in CHO.
This leaves the possibility that conjugated bile acids may activate the apoptotic cascade through Fas receptor in this cell line, as glycine-conjugated bile acids do in hepatocytes [ 25 ] .
Following release into the cytosol, these death-inducing proteins promote apoptotic cell destruction through multiple pathways including caspase activation and nuclear DNA fragmentation.
Besides platelets stimulated by various agonists such as thrombin with collagen or the complement complex C5b-9 [ 7 11 ] , a release of PS-containing membrane MP was demonstrated in other cell types such as endotoxin-stimulated monocytes [ 12 ] , polymorphonuclear leucocytes stimulated with the chemotactic peptide FMLP [ 13 ] or apoptotic T-lymphocytes [ 14 ] .
The normal restriction of PS to the inner surface of the plasma membrane becomes perturbed in apoptotic cells [ 15 16 ] .
5C,5D) indicates that the portion of cell fragments corresponding to apoptotic bodies and necrotic cells was significantly higher in culture treated with 5 µM CPT as compared to culture treated with 500 nM CPT or with 0.
The small size and the absence of nucleic acids indicate that the analyzed MP are different from apoptotic bodies formed in the terminal stage of apoptosis.
We also found this antigen on cell fragments, including apoptotic bodies (Fig.
[ 17 ] reported that the release of PS-containing MP was proportional to hypodiploid DNA in THP-1 and U-937 cells stimulated by various apoptotic agents.
Cell desquamation and massive formation of apoptotic bodies seen after 5 µM CPT treatment did not further enhance the MP-release (Fig.
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