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Given that the effect of averaging is to smooth a time series and potentially emphasize rhythmicity, the absence of obvious periodicity in cry b , as shown qualitatively in the bottom left panel in Figure 2, suggests that the antennal cry b phenotype is typically arrhythmic in LD12:12.
We advocate using these methods simultaneously to maximize accuracy (for example, if Autocorrelation analysis indicates that a signal is arrhythmic we reject any value from MESA because MESA does not evaluate rhythmicity and will return an estimate for any signal).
Discussion Upon release into constant darkness cry1,2 -/-mice immediately become arrhythmic at the behavioral level [ 22 23 ] , at the level of SCN electrophysiology [ 28 ] , and at the cellular/molecular level [ 23 ] .
These findings in cry1,2 -/-mice contrast with the findings of sleep studies in animals that are rendered arrhythmic by lesioning of the SCN.
Although it is unlikely that arrhythmic specimens would give rise to a mean rhythm, it is conceivable that rhythmic specimens might give rise to an arrhythmic mean.
The appearance of rhythmicity in the correlogram is applied as a qualitative criterion so that we do not treat weakly rhythmic data as arrhythmic data.
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