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Chlorotoxin, isolated from Leiurus quinquestriatus haebraeus, shows Cl -channel-blocking activity and causes paralysis due to the inhibition of structurally related anion channels such as the extrajunctional channels of arthropod muscles [ 11 ] .
As stringency increased, 40-83% of proteins were rejected, and the relative nematode branch length (to the arthropod and vertebrate branches) dropped from 16% to 0%.
, that the multiplicity of Runx genes in the vertebrate and arthropod lineages resulted from independent gene duplications within those respective lineages.
Beyond that, low bootstrap values prohibit a confident assessment of evolutionary branching order of the arthropod Runx paralogues, and it is not clear whether they are monophyletic (although the position of the crayfish gene suggests a deep duplication event within in the insect/crustacean clade at least).
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