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Sentences for "autoantibodies "
Immunoglobulins Natural autoantibodies are present in the blood of normal healthy individuals, and they are almost exclusively IgM antibodies, although some IgG and IgA natural autoantibodies can also be detected, that bind to a variety of self-antigens, including self IgG [ 4, 27].
These data indicate that natural autoantibodies exhibit a stage-specific binding to epithelial cells.
Similar stage-specific binding to epidermis was also detected for natural IgM and IgG autoantibodies in normal human sera [ 3].
In the present study, we show that anti-peptide autoantibodies and fatal anaphylactic reactions can be elicited by immunodominant GAD65 peptides in NOD mice that have been injected with these peptides intraperitoneally in incomplete Freund's adjuvant (IFA), as part of an attempt to induce "tolerance" and prevent the spontaneous development of T1DM.
Moreover, while this manuscript was in review, Liu and colleagues reported that anti-peptide autoantibodies and fatal anaphylaxis can be induced in NOD mice that have been immunized with insulin B chain peptides B:9-23 or B:13-23 [ 15 ] .
In addition, a recent report [ 15 ] revealed that SSc autoantibodies bind to CMV late protein UL94 and induce apoptosis in endothelial cells therefore implicating molecular mimicry as a potential mechanism accounting for the link between SSc and CMV.
Recently, it has been reported that IgG autoantibodies from SSc patients bind CMV late protein UL94 and this induces apoptosis in human endothelial cells [ 15 ] .
Other Autoantibodies Antinuclear antibody (ANA) titer was determined by indirect immunofluorescence using Hep-2 substrate.
We found that women with premature ovarian failure are significantly more likely to have positive thyroid peroxidase and parietal cell autoantibodies than women with normal ovarian function.
It is well established that these mice with ovarian autoimmunity also develop circulating autoantibodies against the oocyte cytoplasm, the zona pellucida, and against steroid producing cells [ 22 ] .
Normal animal and human serum are known to contain a wide range of low-titer autoantibodies that have been termed "natural autoantibodies" [ 28 ] .
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