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Sentences for "backcrosses "
While comparisons between a wild type and a mutant that has been subjected to six or seven backcrosses are generally considered acceptable, there is still a small risk of linkage drag, creating the possibility that genes linked to the brown midrib genes are affecting the development.
Using the BXN and their RIX progeny Mapping modifiers of dominant alleles using RI backcrosses Knowing the precise location of breakpoints in RI lines also makes it possible to map modifier loci of mutations by making and phenotyping a set of different F1 crosses made between inbred carrier stock (for example, a knockout carried on a C57BL/6 background) and fully typed RI lines.
There have been sporadic reports of phenotypes initially attributed to deficiency in the expression of a given gene that disappeared with additional backcrosses to B6.
This group has published that Apcs -/- mice on a (129 × B6) genetic background develop a lupus-like disease, even after repeated backcrosses to B6 (Bickerstaff et al.
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