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Such searches, with Redß proteins from different lambdoid bacteriophages as queries, retrieved not only other obvious Redß homologs, but also the RecT protein family.

The second superfamily typified by the ERF proteins is predominantly found in bacteriophages and is also present on all circular plasmids from Borrelia, suggesting a role in the recombination of these plasmids.

Prominent among these alternatives is phage therapy, the use of bacteriophages to kill or otherwise control the bacterial populations in infected hosts.

The majority of the domains with which the KilA-N and Bro-N domains combine in multidomain proteins are restricted to proteins encoded by temperate bacteriophages and large eukaryotic DNA viruses (the exceptions are a few domains that are common in cellular proteomes, such as HTH, CCCH and RING finger).

Some of these enzymes are also encoded by bacteriophages and are used to degrade the host cell wall [ 9, 10, 11].

Furthermore, there is considerable interest in these proteins as they could be potential targets for antibacterial agents, and some cell-wall-hydrolyzing enzymes from bacteriophages themselves function as antibacterial agents.

The Pal lineage of the NIpC-like orthologous group is restricted to the bacteriophages and their prophage remnants in Gram-positive bacteria.

Indeed, the vast majority of bacteriophages being still unknown, they might represent an enormous reservoir of such genes.


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