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Sentences for "benzodiazepine "
Of the genes listed in Table 4, seven were found in both studies (Peripheral Benzodiazepine receptor, 5HT3, Gadd45, CLP36, Lysozyme, SNAP25 and VGF).
We now find several genes that could have a survival-promoting role, including the peripheral benzodiazepine receptor, whose agonists are potent antiapoptotic compounds [ 17 ] , GADD45A, which maintains genomic stability and appears to be anti-apoptotic in neurons after ischemic damage [ 18 ] , metallothionein 1L, which is a free radical scavenger [ 19 ] , GTP cyclohydrolase 1, which is obligatory for the actions of NGF on PC12 cells [ 20 ] , and IES-JE (MCP-1) which attracts macrophages, which in turn have been reported to have a role in neuronal survival [ 21 ] .
When administered to counteract sedative effect, the benzodiazepine antagonist flumazinil quickly normalizes alpha wave activity [ 11].
These proteins include yeast Osh3p, a cytoplasmic oxysterol-binding protein, animal Sec14-like proteins that are involved in secretion, human GCP60 (also called PAP7, a peripheral-type benzodiazepine receptor-associated protein [ 14]), which interacts with the Golgi integral membrane protein Giantin, and several other uncharacterized eukaryotic proteins with different lipid-binding domains (Figure 1).
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