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Sentences for "bilayer "
In similar experiments using mixed PIP 2 /PC vesicles, all of the Boi1-PH stayed in the soluble fraction (data not shown), supporting the views that the composition of the lipid bilayer affects the ability of Boi1-PH to bind PIP 2 and that PS promotes this association.
One possibility is that each of these mutant versions of Boi1 retains at least a slight affinity for PIP 2 and that the myristoyl group causes these mutant PH domains to be apposed close enough to the lipid bilayer to enable the residual PIP 2 -binding activity to now be sufficient for binding to PIP 2 .
We hypothesize that it is unlikely that some members of the TMC family display an atypical topology, thus we propose that the lipophilic intracellular loop between TM6 and TM7 bears some flexibility, which may enable this domain to integrate into the inner surface of the phospholipid bilayer or even to pass through the plasmamembrane (Figure 2).
This lipid does not support the formation of closed bilayer vesicles, but rather forms micelles like a detergent.
Proper interaction with the lipid bilayer may partly explain the phenomenon.
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