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Sentences for "binders "
The opposite, oval to oblong, rather thick, smooth leaves and the somewhat scurfy twigs help the novice to name this common shrub, whose tough, pliable branches make excellent binders for farmer's bundles, but whose leaves cannot be recommended as a substitute for tea.
Positions 5 and 10 are proline and serine, respectively, in the sequence-independent DNA binders as well as in TOX.
For each RNA target, the predicted amino acid sequences of the peptide binders were analyzed in terms of both overall amino acid content and the occurrence of known RNA-binding motifs and consensus domains.
Table 4shows a comparison of the specific amino acid composition of peptide binders with regard to their average frequency of occurrence seen within the original unpanned library.
All of the peptide binders showed enrichment of arginine residues, as would be expected for RNA binding proteins.
In addition, several peptide binders showed the presence of the RGG box (Figure 2A) and one sequence was found that contained the KH motif (Figure 2B), both of which are known RNA-binding motifs [ 8 9 ] .
Sequence analysis of surrogate peptide binders to HCV using MEME (Motif Elicitation Program) and other peptide sequence alignment programs identified a consensus sequence TxRLL found in four peptides binding to the HCV mRNA (Figure 5).
This observation emphasizes the primary goal of structure-based screening procedures, which is to significantly accelerate the initial steps of lead identification projects by automatically discriminating between binders and non-binders, rather than ranking ligands according to their affinity for the receptor.
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