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Sentences for "bioavailability "
The latter precursor has the advantage of small size and its activity is quite tolerant to derivatization at the para-position [ 22 ] , whereas the former is known to have high oral bioavailability and low toxic effects in rats [ 9 ] .
Thus, they were tested against databases predicting plasma protein binding affinity [ 32 ] , oral bioavailability and urine excretion (unpublished results).
Evaluating candidate molecules by the predicted pharmacokinetic parameters (Table 4) we favored those with higher oral bioavailability scores and lower urine excretion scores.
Compounds III with X = O, Y = H and OH in position 1, and compound II with X = S and Y = H were selected as the most promising candidates since their predicted oral bioavailability was among the highest while the potential harmful side effects were predicted to be low (Table 4).
Structural variation (changing X, Y, and the position of the hydroxyl group) can be used for membrane permeability adjustment, enhancement of oral bioavailability and improvement of Blood-Brain Barrier penetration.
iNOS) and rate of NO production, as well as the bioavailability of oxidants in these different models.
Because the M6P/IGF2R is believed to sequester and degrade IGF-II [ 10 ] , a decrease in M6P/IGF2R could result in decreased degradation and hence increased bioavailability of IGF-II to the IGF-I receptor, which mediates the growth-promoting effect of IGF-II.
Therefore, down-regulation of M6P/IGF2R expression could also lead to a decreased bioavailability of activated TGF-ß, thereby decreasing the sensitivity of MCF-7 cells to the TGF-ß apoptotic pathway.
M6P/IGF2R allelic loss would therefore result in enhanced cellular bioavailability of this potent growth factor, thereby potentially increasing both cell proliferation and resistance to apoptosis [ 29 ] .
These findings establish the bioavailability of the drug following this route of administration.
Although we cannot eliminate the possibility of more subtle effects of chemopreventive agents on TGF-ß bioavailability or cellular responsiveness, in our preliminary analyses we have seen no effects on the expression of type I and type II TGF-ß receptors (data not shown).
In addition, higher dietary fiber intake has been associated with higher plasma levels of sex-hormone-binding globulin, which can reduce the bioavailability of estrogens [ 19 ] .
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