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Sentences for "biomarker "
Lysophophatidic Acid (LPA) is a member of this class of compounds, and its plasma levels have been proposed as a potential biomarker for ovarian cancer [ 16 17 ] .
The earliest biomarker evidence of eukaryotes is at 2.
5 Ga [ 13 ] but the biomarker evidence at 2.
However, the 2-methylhopane biomarker of cyanobacteria has been detected in lower abundance in other prokaryotes, and many taxa (especially anaerobic species) have not been examined for the biomarker [ 15 16 17 ] .
We find that the divergence between archaebacteria and the lineage leading to eukaryotes (K A ) was quite early (~4 Ga), which is about the time of the earliest biomarker evidence of life (3.
Also, the estimates for the origin of cyanobacteria and eukaryotes are consistent (within one SE) with the earliest biomarker evidence for those two groups (~2.
First we wanted to link the analysis to the goal of study, namely, to help decide on further study of the biomarker as a trigger for early intervention.
A mammogram is analogous to a biomarker test for cancer but there is extra information from various studies that makes it useful for setting guidelines.
One reason for using FPR and TPR from mammography as a standard is that, unlike biomarker measurements in nested case-control studies, in mammography studies there is a biopsy at the time of a positive test.
This would make the biomarker appear more promising than actually the case.
The implication is that a similar FPR and TPR for a biomarker would lead to an acceptable screening modality.
If a positive biomarker is unlikely to trigger additional diagnostic work-ups prior to biopsy, a higher FPR might be acceptable.
However, because nested case-control biomarker studies provide data on cancer diagnosis, they can be used to estimate a more restricted FPR based on unnecessary biopsies.
To avoid overdiagnosis bias, cases should be diagnosed as a result of symptoms rather than on screening For the TPR in the biomarker study to reflect the true TPR, cases should be diagnosed as a result of symptoms rather than on screening.
The spectrum of conditions could differ considerably if the retrospective biomarker study were embedded in a randomized trial with strict eligibility requirements.
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