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Sentences for "biophysical "
We then consider the mechanical properties of myosin-II that have been measured using modern biophysical tools [ 11 12 13 14 ] to estimate how much myosin-II would be required to generate a particular amount of force.
This analysis provides a useful framework for relating the biochemical and biophysical properties of myosin-II to the mechanical process of cytokinesis.
As dbEST expands over the next few years, new genes may be identified with repeated in silico searches, or with biophysical approaches such as cDNA hybridization [ 40 ] , exon trapping [ 41 ] and amplification [ 42 ] , or by identification of evolutionary conserved sequences [ 43 ] and HTF islands [ 44 ] .
Third, radiation may alter the biophysical structures of tumors, which in some tumors has the capability to impair the infiltration or function of tumor-specific T cells.
However, a more functional way of thinking about the probe length may be how many bases of the probe are actually available for hybridization and if these bases are exhibiting solution phase biophysical behavior.
In retrospect, these data make sense from a biophysical perspective because, at the longer hybridization times, the mismatched duplexes will have dissociated due to their faster dissociation rates (Figure 3), leaving primarily the perfectly matched duplexes.
The role of COP and the biophysical mechanism associated with this rather violent cellular event remains unknown.
Although, the molecular mechanisms associated with each step in the cell death cascade remain unknown, MTX may prove to be an important tool for understanding the biochemical and biophysical links between channel activation, COP formation, and membrane blebbing.
The initial state of the cell/polymer construct was presumably uniform, and the heterogeneous [GAG] accumulation was attributed to differences in the biophysical environment.
In macroscopic terms, water movement through plants had long been thought of as a biophysical problem, as a topic of capillary resistance in pressurized pipes terminating in 'sprinkler' systems - the stomata - whose apertures adjust when responding to changes in hydraulic pressure.
A path forward: reverse genetics and biophysical investigations The use of gene knockout and/or antisense technologies is particularly appealing for plant AQPs.
We believe that applying a combination of biophysical measures of conductivity to transgenics involving each of the AQPs, and combinations of several AQPs, represents the most promising approach to the fundamental unanswered questions about general and individual AQP functions.
Clearly, this level of understanding will require a combination of biophysical measurements - which we think must be nondestructive, real-time and experimentally flexible - transgenic technology, knockout or precision antisense experiments, and modeling of plant function.
At the molecular level, however, the microarray experiment is a challenging biophysical problem that is extremely dependent on probe-target kinetics, specificity and design.
However, it is not clear how to account algorithmically for large pixel-to-pixel variability from the biophysical or statistical standpoint, given that each pixel is supposed to contain an identical distribution of millions of oligonucleotides.
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