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Optical imaging of neural activity evoked by electrical stimulation in the cultured rat suprachiasmatic nucleus (SCN) revealed that the spread of depolarization was inhibited by gap junction blockers (halothane, octanol) but not by a blocker of voltage-depended Na +channels.
Lastly, because MTX is one of the toxins associated with ciguatera seafood poisoning, the identification of U73343 as a potent and relatively specific blocker of MTX-induced cell death cascade may ultimately lead to improved therapeutic interventions.
txt Background Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] .
TEA offers attractive advantages over mercury as a reversible and less toxic blocker for AQP1 channels in experimental analyses of wate ... annel function, however, the relevance of TEA as a blocker for AQP1 channels outside the Xenopus expression system has not been examined previously.
Data presented here show that TEA is effective as a blocker of AQP1 channels expressed in a mammalian renal cell line and in native renal epithelial membrane.
Work presented here provides an additional line of evidence that the pathways for water and ions in AQP1 can be distinguished pharmacologically, using the blocker TEA as a probe.
Just as modern bioinformatics provides immense databases and search tools for molecular structures and polymer sequences [ 16], we envisage that with suitable computational implementation, distributed online models may be queried not only for local pairwise interactions (such as site-site interactions) but also for long-distance chains of events (for example 'Find models where a potassium channel blocker affects cell-cycle progression'), a capability not available in any other approach to biological systems.
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