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Sentences for "cannabinoid "
The authors of the Science paper--"Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal"--suggest in their conclusion that marijuana may be as addictive as heroin and cocaine, and that pot's "subtle disruption" of brain chemistry may leave users " 'primed' for further disruption by other drugs of abuse.
The study found an increase of the neurotransmitter dopamine in rats' nucleus accumbens--often termed "the pleasure center of the brain"--following several cannabinoid injections.
This does not mean cannabinoid research on rodents is worthless.
And when given the choice between a placebo and the cannabinoid blocker, rats choose the blocker.
A few G-protein coupled receptors such as cannabinoid receptor, GABA-B R2 receptor, and olfactory receptor-like protein (SCRD-9), as well as molecules important in signaling such as Galpha(olf), Guanine nucleotide releasing factor, and CAM kinase I beta 2, CAM kinase II beta, and PKC beta were also identified to be expressed more in the dorsal spinal cord.
Certainly I see…antagonism of some of these pathways that nicotine activates or the complementary activation of the cannabinoid pathways as very important targets for therapeutics with respect to the anorexia that's associated with chemotherapy.
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