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Sentences for "cardiomyopathy "
The first autosomal dominant form of cardiomyopathy was mapped in 1994 to the centromeric region of chromosome 1 [ 9 ] .
An additional 98 unrelated subjects with dilated cardiomyopathy were screened by SSCP and DHPLC and found not to carry the 908_909delCT mutation.
Conduction disease preceded the development of dilated cardiomyopathy in the proband's family [ 1 10 ] .
Abbreviations DCM, dilated cardiomyopathy EDMD, Emery Dreifuss Muscular Dystrophy LGMD, limb Girdle muscular dystrophy SSCP, single strand conformation polymorphism DHPLC, denaturing high pressure liquid chromatography LMNA , lamin A/C gene Competing Interests None declared.
At 10 days of age, the proband was noted to have a heart murmur and an echocardiogram revealed at that time, hypertrophic cardiomyopathy with moderate left ventricular hypertrophy and a left ventricular shortening fraction of 30%.
Her cardiomyopathy has improved and the results of her last echocardiogram showed mild left ventricular hypertrophy and a left ventricular shortening fraction of 50%.
A cardiomyopathy screen was negative for the 6 point mutations in mtDNA reported in patients with cardiomyopathy: A3243G, C3303T, A4269G, A4300G, G8363A and T9997C.
No other mutations in these regions, including the 6 point mutations reported in patients with cardiomyopathy as stated above, were detected.
In an animal model of cardiomyopathy that has many similaritiesto human heart failure, we tested the hypothesis that a reductionin apoptosis may be responsible for the beneficial effects of carvedilol.
Discussion Effect of Carvedilol on a Heart Failure Model The furazolidone-induced turkey model is a well characterizedexperimental model of dilated cardiomyopathy with features verysimilar to those found in human heart failure [ 19 20 21 22 ] .
Animals with dilated cardiomyopathy which received carvedilolshowed significant improvement in LV systolic function after 4 weeks.
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