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Sentences for "carnitine "
Measurement of carnitine levels showed no evidence of carnitine depletion.
It has been noticed that if a patient is suspected of having a mitochondrial disease, abnormal carnitine esters may help with the diagnosis, [ 38 ] and abnormal acylcarnitine profiles do not exclusively indicate fatty acid oxidation disorders [ 39 ] .
Although the abnormal carnitine ester present in the proband is elevated in organic acidemias and is not usually present in mitochondrial cytopathies, we speculate that due to compromised ATP synthesis, secondary alterations may be generated in these patients by changes in mitochondrial protein synthesis, decrease in Krebs cycle intermediates and increased free radical formation, that could be responsible for a secondary impairment of mitochondrial biotin dependent carboxylases, but further elucidation is necessary before we could arrive to a conclusion in this regard.
Cpt1 transfers acyl residues from CoA to carnitine in the intermembrane space of the inner mitochondrial membrane, and has a regulatory role in controlling hepatic ß-oxidation [ 50 ] .
The patient's other medications on admission were carnitine and low-dose L-thyroxine for hypothyroidism, she had been taking both for several years.
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