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Sentences for "centromere "
Given the role of the centromere as a checkpoint for regulation of the mitotic phase of the cell cycle [ 50 51 ] , it was hypothesized that C/EBP?
localization around the centromere could play a role in C/EBP?
regulation of the cell cycle [ 49 ] .
The disease was initially linked to an 8 centiMorgan region spanning the centromere of chromosome 12, and then further refined to a critical region of 3 cM [ 1, 2].
Discussion The critical region for the congenital eye movement disorder, CFEOM1, has been reduced to a 3 cM region at the centromere of human chromosome 12 [ 2].
The effort to identify the CFEOM1 disease gene is continuing with analysis of other genes and expressed sequence tags from the critical region at the centromere of chromosome 12.
We previously mapped a CFEOM1 locus, referred to as FEOM1, to a ?
3 cM region spanning the centromere of chromosome 12, flanked by D12S1584 (AFM136xf6) on the p-arm and D12S1668 (AFMb320wd9) on the q-arm [ 6 15 ] .
It will be interesting to determine if checkpoint proteins have a role in centromere function, or mating-type silencing, both of which require intact heterochromatic structures.
Horizontal arrowheads with "Cen" and "Tel" indicate the orientation of the centromere and q-telomere respectively.
The ARS frequency in chromosomal regions that consist of multiple repetitive elements, however, such as the centromere and telomere, may be reduced, meaning that these regions may not be isolatable by the original TAR method.
Cytokeratin 8, transcribed telomere to centromere, is located in the intron between exons 1 and 2 of KIAA0319 (transcribed centromere to telomere).
Also, two small, tightly-spaced clusters of STRPs are included in Set 12 (six STRPs near the centromere of chromosome 11 and three STRPs on the short arm of chromosome 1) for the purpose of gauging linkage disequilibrium.
Although our study found evidence for a region with tentative linkage on chromosome 7q, the region identified in this study is near the telomere and does not overlap with the region of suggestive linkage near the centromere on 7q identified in Onda et al.
Precocious separation of sister chromatids during MI [ 44 46 ] can also produce diploid meiotic products, 67% of which would be heterozygous for centromere markers (Figure 5D) [ 38 ] .
Our observation that rec12-117 mutants produce a high frequency of viable diploid meiotic products, about half of which are heterozygous for centromere linked markers (Figures 4, 5, Table 2), provides a straightforward reason for the discrepancy: The previous study failed to exclude diploid spore colonies and scored only for double prototrophic recombinants (the double auxotrophic, reciprocal recombinants were not analyzed).
Rec12 has dual roles in chiasmatic and achiasmatic (distributive) chromosome segregation during Meiosis I In the absence of crossover recombination (chiasmata) and a backup distributive (achiasmatic) system for chromosome segregation, MI nondisjunction should occur and 100% of any resulting diploid spore colonies would be heterozygous for centromere linked markers (Figure 5B).
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