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Sentences for "cep "
Furthermore, in an in vitro model of angiogenesis, normal vascular development has been shown to require the presence of the CD45 +/c-Kit +/CD34 +hematopoietic stem cells [ 58], which are similar and may be related to adult CEP cells.
It has been reported that CEP cells are able to participate in new vessel growth in a variety of animal models, including the rabbit ischemic hind limb model [ 59].
In patients with inoperable coronary disease, increased circulating VEGF-A resulting from transfection of myocardium with VEGF165 cDNA led to a significant mobilization of CEP cells [ 31].
Further studies of how CEP cells are released from bone marrow and to what extent they participate in postnatal angiogenesis will certainly provide valuable information regarding the therapeutic potential of CEP cells.
The possibility of using CEP cells, both alone and in combination with different angiogenic growth factors, represents a promising means of obtaining stable vessels.
Finally, since the use of CEP cells would allow easy ex vivo gene transfer, combining growth factor-induced therapeutic angiogenesis with gene therapy delivered via CEP should also be a promising approach.
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