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Sentences for "cerebrovascular "
Clinical covariates include hypertension, cardiovascular disease (prevalent heart disease, peripheral vascular disease, or cerebrovascular disease), maximum thickness of the internal carotid artery, depression (CESD score), serum albumin, serum cholesterol, and serum creatinine.
, from cerebrovascular stroke and neurotrauma) [ 1 2 3 4 5 ] and, 3) decreases the risk and delays the onset of neurological disorders such as, Alzheimer's disease [ 4 5 ] .
They completed a questionnaire on risk factors for atherosclerosis including family history of coronopathy, smoking, high blood pressure, personal history of coronopathy or myocardial infarct, history of cerebrovascular disease or occlusive peripheral disease.
Probands are not enrolled if any of the following conditions apply: 1) The index stroke is presumed to be iatrogenic - that is, onset of symptoms occurred within 48 hours after an invasive cerebrovascular or cardiovascular procedure, such as coronary artery bypass grafting, a catheter-based procedure on carotid or coronary arteries, carotid endarterectomy, heart valve surgery, or thoracic or thoracoabdominal aortic aneurysm repair.
Thus, genetic factors that lead to the development of cerebrovascular disease and stroke in children with Hb SS are not well understood.
It is likely that the co-inheritance of one or more of these mutations in sickle cell disease would tip the balance toward a hypercoagulable state and act as an additional risk factor for the development of cerebrovascular disease.
TCD remains the only proven indicator of cerebrovascular disease and stroke risk in Hb SS.
Therefore, a large case-control association study of the role of genes in the development of cerebrovascular disease and stroke risk based upon TCD, is likely to provide more accurate information and may resolve the controversial results obtained in smaller studies [ 5 ] .
In summary, we have designed a case-control association study to elucidate the role of genetic polymorphisms as risk factors for cerebrovascular disease, measured by a high TCD velocity, in children with Hb SS.
The genomewide screen for a large number of SNP markers may uncover the association of novel polymorphisms with cerebrovascular disease and stroke in sickle cell disease.
Based on these power analyses we conclude that we have good power to detect realistic differences in frequencies of alleles that increase risk of cerebrovascular disease and stroke in cases as compared to controls.
We propose to use a combination of a candidate gene association study and genomewide association scan in children with Hb SS at high (230 cases) or low (400 controls) risk for cerebrovascular disease as determined by their TCD velocity.
We therefore believe that hidden stratification is unlikely to be a problem in our case-control study of African-American children with sickle cell disease at high or low risk for cerebrovascular disease based on their TCD values.
In conclusion, we believe that our dual approach of a candidate gene and whole-genome association study will yield important information on genetic risk factors for cerebrovascular disease in sickle cell disease.
The NIS database contained 384,968 (377,544) patient discharges with a principal or secondary (first code reported) diagnosis of cerebrovascular disease.
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