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Sentences for "chimera "
The person of whom I speak seemed born for the purpose of foreshadowing the doctrines of Turgot, Price, Priestley, and Condorcet-of exemplifying by individual instance what has been deemed the chimera of the perfectionists.
If all disputes over abstract ideals are, as Fish says, attempts to exploit an elevated moral language for partisan advantage, then to hell with his critics and their faith in chimera such as free speech and scientific objectivity! To hell with conservatives and their absolute values! To hell with liberals and their cherished notion of tolerance, since the people who benefit from it (such as fundamentalists and supremacists) would punch a liberal silly if they found one in a dark alley.
Like wild-type Pop2p, the reverse Pop2p-N/Pop1p-C chimera localizes to both the nucleus and the cytoplasm, again indicating that Pop1p, but not Pop2p, has a functional NLS in its N-terminus (R.
We also observed a reduction in basal JNK activity in normal cells expressing this chimera and in v-crk mediated activation of JNK in cell expressing both v-crk and the chimera.
Finally, we show that this chimera can act as a decoy to selectively disrupt signaling events downstream of the tyrosine phosphorylated SD of endogenous Cas, acting as a dominant negative mutant.
Figure 4ademonstrates that while the chimera was not stably tyrosine phosphorylated when expressed alone, expression of the Src KM/Cas(SD) chimera along with either WT or an SH3 domain mutant of v-crk resulted in its stable tyrosine phosphorylation and co-immunoprecipitation with v-crk (Fig.
Suppression of v-crk mediated transformation by tyrosine phosphorylated Cas SD As our tyrosine phosphorylated Cas SD chimera can interact with v-crk, we decided to find out if the chimera would affect cell growth and/or transformation in normal cells and those transformed with v-crk.
Analysis of the effect of this chimera in non-transformed NIH3T3 cells indicates that these cells were not transformed and had normal morphology, although they grew slightly slower than vector-transfected cells (data not shown).
Analysis of the growth of either non-transformed or v-crk transformed NIH3T3 cells in soft agar confirmed that expression of tyrosine phosphorylated Cas SD chimera did not transform NIH3T3 cells as no colonies of these cells grew in soft agar (data not shown).
Instead, expression of tyrosine phosphorylated Cas SD chimera resulted in significant reduction in the number of v-crk/NIH3T3 soft agar colonies as well as their size (Fig.
In determining which pathways are affected in our stable cell lines generated, we determined if JNK was activated in the v-crk transformed cells, and if the tyrosine phosphorylated Cas chimera was affecting this activation.
JNK was immunoprecipitated and tested for activity from control NIH3T3 cells, those expressing the Cas chimera and those expressing the Cas chimera and v-crk (Fig.
We found that while JNK activity was elevated in v-crk transformed NIH3T3 cells, expression of the tyrosine phosphorylated Cas chimera resulted in reduced activity of JNK (Fig.
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