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Sentences for "chimeric "
Assembly of chimeric heterodimers formed by mixing subunits of HIV-1 RT and FIV-1 RT, has demonstrated that the p51 subunit of HIV-1 RT helps to preserve the functional integrity of the HIV-1 RT heterodimer [ 18 ] .
p35-C/EBPß was expressed as a chimeric GST protein and immobilized on glutathione-agarose beads.
To characterize the cellular roles of PP5 we have, therefore, developed chimeric antisense 2'- O -(2-methoxy) ethylphosphothioate oligonucleotides capable of inhibiting the expression of human PP5 at nanomolar concentrations.
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/MGSA and IL-8 have also been shown to enhance re-epithelialization of human skin grafts in chimeric mice [ 29 38 ] .
We have tried to address this problem by constructing a chimeric Cas molecule (Src*/Cas(SD)) that is phosphorylated independently of upstream signals by fusing the SD of Cas to a Src kinase domain that had been attenuated by mutating the activation tyrosine (Y 416) to phenylalanine.
We describe a novel chimeric molecule approach that allows the analysis of signaling events regulated by adaptor proteins that require tyrosine phosphorylation by upstream signals for which we used the Cas protein as a model.
We propose that our chimeric approach can be used to identify Cas binding proteins in mammalian cells in the absence of specific upstream signals normally required for tyrosine phosphorylation of the Cas substrate domain.
This chimeric approach can also be extended to other adaptor proteins that require upstream signals for tyrosine phosphorylation, creating tyrosine phosphorylated decoys or targeting tyrosine phosphorylated substrate domains or full length adaptor proteins in transgenic cellular and animal systems.
Tissue culture experiments using DT-sensitive transfected mouse fibroblast cell lines expressing on the cell surface both the monkey DT receptor and chimeric mouse-monkey CD9 antigen showed that the second extracellular domain of monkey CD9 antigen is able to act as a coreceptor for DT and is also responsible for the increased DT-sensitivity and affinity for DT in these cell lines [ 9 ] .
pCMV5 expression vectors containing Rab24 and Rab1B were engineered by overlap-extension PCR to encode the following chimeric proteins: Rab24/Rab1B, consisting of residues 1-165 of Rab24 [ 24 ] fused to residues 163-201 from Rab1B [ 80 ] , Rab24(D123I)/Rab1B, consisting of residues 1-165 of Rab24 with the D123I substitution, fused to residues 163-201 of Rab1B, Rab1B/Rab24, consisting of residues 1-162 of Rab1B fused to residues 166-203 of Rab24, and Rab1B(N121I)/Rab24, consisting of residues 1-162 of Rab1B with the N121I substitution, fused to residues 166-203 of Rab24.
Transgenic mice and embryos can be generated from these ES cells by standard injection into blastocysts and subsequent breeding of the resulting chimeric mice.
The targeted ES cells, originally derived from strain 129X1/SvJ [ 22], were injected into C57BL/6J blastocysts, and the resulting chimeric mice were bred to C57BL/6J females to pass the mutation through the germ line.
This ubiquitous expression of EYFP or ECFP was heritably transmitted to the following generations (data not shown), resulting in ubiquitously expressing lines of mice that will be useful for lineage tracing in chimeric mice or embryos, analogous to the original ROSA26 lacZ promoter trap strain [ 21].
This approach involves the use of a drug-inducible chimeric receptor consisting of the extracellular and transmembrane spanning portions derived from the hamster ß 2 adrenergic receptor (ß 2 AR) and the intracellular domains derived from Rfz-2.
C57mg cells stably transformed with Rfz-2/ß 2 AR retrovirus or wt C57mg cells were treated overnight with propranolol, a ß 2 AR antagonist, to maintain the chimeric receptors in an inactivated state.
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