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Sentences for "chlamydial "
The function of this gene family in chlamydial growth and development remains unknown.
The availability of complete genomic sequences for different species has provided a contemporary impetus for research to uncover specific relationships of chlamydial genes with the disease process, an impetus that is particularly welcome because the fastidious growth requirements of the organism have made it relatively intractable to experimentation.
One of the most prominent host protective responses to chlamydial infections has been the production of the T-cell-derived pro-inflammatory cytokine IFN-?
.
The biological relationship of IFN-?
, indoleamine dioxygenase, tryptophan limitation and the persistent state of intracellular parasitism extends beyond chlamydial parasites, as illustrated by consideration of Toxoplasma gondii [ 20].
Results and discussion Dynamic gene reorganization and gene flux within the chlamydial plasticity zones Figure 1shows the gene organization in C.
[ 29] note that if the chlamydial cytotoxin inhibits lymphocyte activation (as does LifA in E.
The import of ATP (substrate for PRPP synthase) from the host is also probably needed, and the presence of ATP translocases in chlamydial genomes has been documented [ 1, 2, 3].
psittaci is probably derived from ancestral chlamydial genes before modern events of gene reduction occurred.
psittaci from other chlamydial lineages), one might then expect the genes to have GC contents different from that of the overall C.
psittaci operon gene would not include other chlamydial genes and would be dominated by one organism having an appropriate GC content.
Deterioration of tryptophan-pathway genes in the chlamydiae Chlamydial species have generally undergone reductive evolution that includes an inability to synthesize tryptophan from chorismate.
coli with those from chlamydial species.
psittaci, not present in the other two chlamydial species (V292 › T292 and S429 › T429) are conservative changes that are presumably tolerated.
Figure 7presents an unrooted radial tree that shows the chlamydial proteins to comprise a distinct cluster.
The chlamydial sequences are approximately equidistant from the TyrP/Mtr-TnaB groupings.
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