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Sentences for "cholestatic "
In McNtcp cells, which are liver-derived cells engineered to transport bile acids actively [ 17 ] , taurine-conjugated bile acids induce the formation of intracellular vesicles that resembles structures observed in cholestatic liver cells without apparent cellular cytotoxicity [ 1 18 ] .
We now report a severe systemic reaction to SSZ in a 21-year-old female with rheumatoid arthritis characterized by granulomatous infiltration of the bone marrow, colon and small bowel as well as cholestatic hepatitis and seizures.
Our patient had severe cholestatic hepatitis with coagulopathy.
Although Still's disease can rarely lead to hepatic involvement with cholestatic hepatitis, the prior history of rheumatoid factor seropositivity and a low serum ferritin level made this diagnosis unlikely [ 21 ] .
The pattern of biochemical liver abnormalities was mainly hepatocellular (defined as predominant increase of AST and/or ALT in comparison with AP and/or bilirubins) in 11 cases, cholestatic (defined as predominant increase in AP and/or bilirubins compared with AST and/or ALT) in 3 and mixed (evidence of both cholestatic and hepatocellular damage) in 8 cases.
Other studies have reported variable prevalence [ 3 28 ] and different histopathological findings in liver biopsies ranging from cholestatic liver damage (stage I primary biliary cirrhosis) to chronic active hepatitis due to hepatitis C virus.
In our review of cases, we found predominance in hepatocellular liver damage rather than cholestatic disease, which would argue against a PBC-type of liver damage.
While inflammation is an important element in the defense against infection, it can also contribute to cholestatic biliary diseases and cholelithiasis.
Some studies have suggested that excessive amino acids, hepatotoxic bile acids, bacterial overgrowth, sepsis, micronutrient deficiency, and TPN contaminants all contribute to cholestatic liver injury [ 4, 5, 6].
However, the mechanisms of liver injury in cholestatic diseases in infants remain unclear.
Animal studies using models of surgically induced extrahepatic biliary obstruction have also shown that lipid peroxidation products - specifically, malondialdehyde (MDA) - are increased in the cholestatic liver [ 8, 9].
The identification of ROIs as potential markers of liver injury in cholestatic preterm infants may aid in the diagnosis and management of those at highest risk for ongoing liver impairment.
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