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Sentences for "chromatin "
-This structure has not been conclusively[Pg 136] proved to exist, but in some bacteria chromatin particles have been observed near the centre of the bacterial cell and denser masses of protoplasm situated at the poles which exhibit a more marked affinity than the rest of the cell protoplasm for aniline dyes.
In ligand blotting assays, ProT?
bound only to chromatin pools and nuclear fractions where histone H1 was present [ 71 72 ] .
The analysis of the interaction of ProT?
with H1-containing chromatin suggests a putative role for ProT?
in the fine-tuning of the stoichiometry and/or mode of interaction of H1 with chromatin [ 73 ] .
Interestingly, HL-60 cells overexpressing ProT?
show an enhancement of accessibility of micrococcal nuclease to chromatin, implying relaxed chromatin structure for enhanced cell cycle gene expression [ 74 ] .
Transcription and chromatin remodeling factors A highly ordered chromatin structure presents a physical obstacle for gene transcription, presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] .
A weak intrinsic HAT activity has been reported in SRC-1/NCoA-1 and pCIP/ACTR/AIB1, suggesting that chromatin remodeling may also be a function of these NCoA factors [ 99 100 ] , although they do not appear to contain regions homologous to the HAT domains of CBP/p300 or p/CAF.
Promoter activity in later branching eukaryotes is greatly modulated by enhancer and repressor sequences which have no activity of their own but are the targets of DNA biding proteins or protein complexes which can remodel the promoter chromatin to make it more or less accessible to RNA polymerase.
Biochemical assays have shown that the action of ATP-dependent chromatin remodelling activities increase the accessibility of DNA within chromatin templates.
cerevisiae SWI/SNF [ 3 ] , Ino80 complex [ 4 ] , Drosophila NURF [ 5 ] are examples of some high molecular weight chromatin remodelling factors which can facilitate transcription by binding to chromatinized DNA templates.
However, none of the above chromatin remodelling factors binds to specific DNA sequences.
Other studies have demonstrated that acidic activators can relieve nucleosomal repression and that the anti-repression function may be mediated by chromatin remodeling systems [ 39].
Deletion of this acidic cluster of BLM has an effect on localization and SCE frequency and may target BLM to RPA bound to single-stranded DNA, or it may allow BLM to function with chromatin remodeling complexes at sites of ectopic invasion events.
Since CBP/p300 has intrinsic histone acetyltransferase (HAT) activity and participates in chromatin remodeling, the recruitment of CBP/p300 into the DNA-binding complexes of Smad1 and Smad4 is likely a critical step in Smad-regulated gene activation.
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Example sentences with the chromatin , a sentence example for chromatin , and
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