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Sentences for "cisplatin "
They also received two cycles of cisplatin and 5-fluorouracil during the first and sixth weeks of irradiation.
However, 20-30% of the patients with metastatic disease exhibit resistance to the cisplatin curative regimen leading to high mortality in this group.
Addition of Gleevec to A549 cells with cisplatin induced cell death synergistically, suggesting Gleevec can potentiate the cisplatin effect on A549 cells.
The concentration of Gleevec to inhibit 50% cell growth (IC50) was estimated to be around 2-3 µM (Figure 1), whereas the IC50 of cisplatin on A549 cells was estimated to be 64-70 µM (Figure 2).
Gleevec potentiated the cell-killing effect of cisplatin One of the major reasons of testing Gleevec for treatment of non-small cell lung carcinoma is to see if the specific tyrosine kinase inhibitor Gleevec, and other potential small molecules currently on clinical trials, can be used as an adjuvant therapeutic agent in combination with conventional chemotherapy.
We used the IC50 concentrations for both Gleevec and cisplatin to treat A549 cells in culture, and assessed the viability of the cells by MTT assays at the different time points (Figure 4).
Combination of Gleevec and cisplatin synergistically inhibited the growth of A549 cells (Figure 4).
This synergistic effect of Gleevec and cisplatin on A549 lung cancer cells were not seen for human 293 kidney cells (Figure 5).
Synergistic effect of Gleevec and cisplatin on A549 cells We have shown that Gleevec can exert its effect synergistically with cisplatin.
Our results suggest that inhibition of tyrosine kinase activity of the potential targets by Gleevec appear to potentiate the effect of cisplatin in DNA-damage induced apoptosis in A549 cells.
Current study results suggests that Gleevec can potentiate the cisplatin effect on A549 lung cancer cells, and these findings provide important in vitro data for further testing the possibility of using Gleevec as adjuvant therapy for clinical lung cancer patients.
The experimental procedure for the cisplatin and Gleevec treatment was the following: The A549 cells and human 293 cells were plated into the 96 well plates at the cell density indicated and the cells were allowed to attach overnight.
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