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Sentences for "coccidioidomycosis "
txt It has been more than a century since coccidioidomycosis was first recognized as a serious disease, and its etiology and epidemiology have been well documented.
Etiology and Epidemiology Coccidioidomycosis is a fungal disease found only in the Western Hemisphere.
Endemic regions for coccidioidomycosis have long been identified in semiarid areas in Mexico [3], and smaller endemic foci have been described in areas of Central and South America [4,5].
75% of extrapulmonary coccidioidomycosis cases and requires treatment for life [16].
Tuberculosis and coccidioidomycosis share common epidemiological, clinical, radiographic, and even histopathological features, making a correct diagnosis extremely difficult in cases where both diseases coexist.
Unfortunately, information on the treatment of coccidioidomycosis is limited, due to the small numbers of controlled trials performed for what is perceived to be a niche market.
Immunology and the Basis for a Vaccine Acquired resistance to coccidioidomycosis strongly correlates with the development of a delayed-type hypersensitivity skin test response to coccidioidal antigens [23] and the production of T-helper-1 (Th1)-associated cytokines to coccidioidal antigens, such as interferon-gamma (IFN-?
) and Interleukin-2 (IL-2) [24].
In cases of marked immunosuppression, either in advanced AIDS or other forms of depressed cellular immunity, the management of coccidioidomycosis is particularly challenging and requires aggressive treatment [26].
Conclusion Although the vast majority of infected individuals emerge from coccidioidomycosis without complications, an unlucky minority are faced with a debilitating disease that lacks adequate drug options for rapid and completely effective treatment.
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