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Sentences for "cofactors "
These cofactors interact with nuclear receptors in a ligand-dependent manner and enhance transcriptional activation via histone acetylation/methylation and recruitment of additional cofactors such as CBP/p300 [ 89 ] .
The fact that the binding of PEDF to cell surfaces decreases with heparin/HS depletion, implies that heparin/HS molecules might act as cofactors for PEDF-receptor interactions.
The data obtained so far on the action of PEDF on different cells may have not considered the presence of these cofactors in the media.
For each in silico deletion strain, the optimal production of the twelve biosynthetic precursors and the metabolic cofactors was also calculated to identify auxotrophic requirements and impaired functions in the metabolic network (Table 1).
Specifically, the gltA -, icdA -, and acnAB - in silico deletion strains were unable to produce one biosynthetic precursor (?
-ketoglutarate, Table 1), and retained the capability to synthesize the remaining biosynthetic precursors and cofactors nearly equivalent to the wild-type.
Here, transcription factors are defined as proteins which recognize and bind regulatory sites and have a potential to modulate directly or indirectly through the recruitment of cofactors the activity of the basal transcriptional apparatus of proximal genes.
It will be interesting to see how well Ahab performs in situations where the concerted binding of cofactors constrains the spacing of binding sites [ 13 14 ] .
We know too little about the physical binding energies of transcription factors, and their cofactors and protein concentrations in vivo, to calculate whether any modules are actually occupied by factors.
Some are the basic building blocks of nucleic acids, some like ATP and GTP, are additionally, cellular energy stores, others like cAMP or cGMP are messengers in signal transduction, and, yet others, such as FAD, NAD, thiamine phosphates and pyridoxal phosphate are cofactors for a range of enzymes [ 1 2 ] .
Interestingly, our unpublished in vitro observations and published data showing marked expression of basic fibroblast growth factor in the interstitium of HIVAN kidneys [ 35 ] suggest that soluble mitogens may be important cofactors with HIV-1 expression to induce cyclin D 1 .
There is an urgent need to follow cohorts at-risks children and adolescents to investigate cofactors acting in concert with obesity that are responsible for the early onset of risk factors for cardiovascular diseases, a phenomenon increasingly being observed in many populations.
When APC is rendered inactive by mutation, ß-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .
Zn-ribbons are present in a variety of nucleic-acid-binding proteins, including several ribosomal proteins, translation factors, aminoacyl-tRNA synthetases, RNA polymerase cofactors in archaea and eukaryotes, and several transcription factors.
The RRM-like domain and the ASCR domain are positioned in the exterior entrance to the catalytic cleft and could interact with cofactors or with nucleic acid.
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