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Sentences for "collagens "
Therefore, we tested whether cCAF affects the production or activity of the gelatinases MMP-2 or MMP-9, or the collagenase MMP-1, all of which digest collagens I and III.
As shown in Figure 1, histology (Panels A and E) and immunohistochemistry for Collagens II and X (Figure 1, Panels C, D and G, H) revealed appropriate cellular morphology, as well as increase in cell size towards hypertrophy (Figure 1, Panels E, G, H), and extracellular matrix production (Figure 1, Panel F).
Figure 3shows that Hoxc-8 transgenic chondrocytes morphologically appeared normal and were able to produce Collagens II and X, and sulfated proteoglycans (Panels C, G, I, D, H, J and B, F respectively).
Specifically, we have focused on MMP-1 and MMP-13, interstitial collagenases that have the unique ability to initiate cleavage of the triple helix comprising the stromal collagens types I, II, and III.
This relationship, along with the combination to the intracellular MYND domain and the lack of signal peptides, suggests that the Egl-9 family proteins are prolyl hydroxylases that modify intracellular proteins, unlike the classic prolyl hydroxylases that have been implicated primarily in the modification of collagens in the endoplasmic lumen.
CD36 is widely expressed and may interact with multiple extracellular ligands, including thrombospondin-1 (TSP-1), long-chain free fatty acids (FFAs), modified (oxidized) low-density lipoprotein (ox-LDL), advanced glycation end (AGE) products, and collagens I and IV [6].
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