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English words and Examples of Usage
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Sentences for "colorectal "
Medical advocacy groups are pushing a home test for colorectal cancer, it requires patients to collect six fecal samples and mail them to a lab.
This feature is not restricted to receptor-like phosphatases as it is also present in a number of adhesion receptor genes, including E-cadherin, N-cadherin, P-cadherin, N-CAM, deleted in colorectal cancer (DCC), axonin-1 and F11 (discussed in [ 12]).
Examples include RPs L7a, L37 and S14 in prostate tumors and cell lines [ 20 ] , RPs L5, L7A, L18, S3, S6, S8, S12, S13, S28, P0 and P1 in colorectal cancers and cell lines [ 21 22 23 24 25 26 ] , L5 in astrocytomas [ 27 ] , L18a in squamous cell carcinoma [ 28 ] , L19 in breast tumors that over-express erbB-2 [ 29 ] , RPs S3A, S4, and S17 in lymphoid malignancies [ 30 ] , L38, S4, P0, and P1 in rhabdomyosarcoma cell lines [ 31 ] , and P0, P1, P2, L5, L9, L35, L39, S3A, S10, and S17 in liver tumors [ 32 ] .
However there are some notable exceptions, including studies of the effect of beta-carotene on cardiovascular mortality [ 6 ] [ 7 ] , the effect of hormone therapy on the rate of cardiovascular disease [ 8 ] , the effect of epidural analgesia on the probability of Cesarean section [ 9 ] , the effect of beta-blockers on mortality [ 10 ] , and the effect of aspirin on the risk of colorectal cancer [ 11 ] .
A possible example would be an analysis of surgical removal of liver metastases in patients with colorectal cancer.
15 (these values are based roughly on data from a colorectal cancer screening trial [ 4 ] ), and d =.
To determine if the upper bound is reasonable, we estimated its value using data from screened subjects in randomized trials of colorectal cancer screening [ 12 13 ] , breast cancer screening [ 14 ] , and lung cancer screening [ 15 16 ] .
We illustrate the methodology using data from the Polyp Prevention Trial (PPT) in which 2079 men and women with recently removed colorectal adenoma were randomized to receive either intensive counseling to adopt a low-fat diet (intervention) or a standard brochure on healthy eating (control) [ 14 ] .
However because, "eligible subjects had no history of colorectal cancer, surgical resection of adenomas, bowel resection, the polyposis syndrome, or inflammatory bowel disease" [ 14 ] , it is unlikely that many subjects had an unobserved high-penetrance gene related to the recurrence of adenomas.
The decline in incidence, and hence mortality, from colorectal cancers is most likely attributable to an increase in recommendations to perform routine screening on average risk individuals and to improved screening techniques [ 2 ] .
Evidence from human studies has largely come from epidemiological data indicating that aspirin and other NSAIDs can reduce the relative risk of developing colorectal cancer by approximately 40-50% [ 13 14 15 16 ] .
The NSAID sulindac has been shown to cause regression of colorectal adenomas of patients with hereditary forms of polyposis (Familial Adenomatous Polyposis (FAP) and Gardner's Syndrome) [ 17 18 19 ] and in sporadic colorectal adenomas [ 20 ] .
Defects in the APC tumour suppressor gene are thought to play a role in greater than 70% of all colorectal cancers and is responsible for inherited syndromes of polyposis (FAP and Gardner's) [ 24 25 ] .
Furthermore, in humans the majority of colorectal cancers arise from adenomatous polyps [ 26 ] .
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