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To test the latter hypothesis, we compared the total ß1 integrin distribution with the distribution of the fraction of ß1 integrins complexed with CD98 on HT 1080 cells (Fig.

Although ß1 integrins were predominantly present in the dense membrane fraction on a sucrose gradient, the subset of ß1 integrins complexed with CD98 was localized to the 'light' membrane fractions.

Accordingly, we have found that a Myo1c fragment containing only IQs 1-3, partially complexed with calmodulin, binds avidly to hair-cell receptors, excess calmodulin blocks this interaction, probably by binding to an unoccupied IQ site on the Myo1c fragment [ 13 ] .

Recent crystal structures of huAPE1 complexed with DNA containing an abasic site [ 9 10 11 ] , combined with sequence analysis and site-directed mutagenesis, have defined the residues that participate in metal ion based cleavage of the phosphate backbone of the DNA [ 12 13 14 15 16 17 ] .

However as a defense mechanism, availability of iron for the bacteria is limited in the host as most of it complexed to ferritin, transferrin, hemoglobin, heme and hemosiderin [ 1 2 3 4 ] .

2 angstrom NarL-DNA structure for NarL-C-terminal domain complexed to a synthetic 7-2-7 NarL consensus binding site where the protein causes a conformational change of B-DNA to A-DNA (Ann Maris, personal communication).

This result suggests that short sequences are capable of stimulating transcription when complexed with promotor elements and that their effect is amplified by increasing the total content of such short sequences.

The second transesterification results in exon ligation with the release of lariat RNA complexed with the intron-encoded protein.

Virus-specific CD8+ T-cell response in the blood Virus-specific CD8+ T-cells were quantitated in the blood of both animals at days 0, 4, and 12 postinfection using 3 tetrameric Mamu-A*01 molecules complexed with the SIV mac Gag 181, Env 622, and Tat 28 peptides (T.

Materials and Methods Modeling of RAR-alpha ligand binding pocket The crystal structure of RAR-?

-LBD complexed to all-trans RA was used as a template [ 18] and the three residues in the vicinity of the ligand which are not conserved between the two isoforms were modified accordingly: A234, M272, and A397 were changed to S234, I272 and V397 respectively.

We address this problem by performing Molecular Dynamic (MD) simulations on HIV-1 protease-inhibitor complexed and using the resulting structures to calculate the binding energies by AutoDock, a ligand flexible docking program.

8% silybin complexed with phosphatidylcholine.

In its inactive form MMP-9 is complexed to TIMP-1 [ 34].

Pro-MMP-2 complexed with TIMP-2 binds to a TIMP-2 binding site on the membrane-bound MMP-14 receptor, and through a conformational change the catalytic domain becomes exposed forming the active enzyme complex.

The gadolinium (Gd) was used to separate intracellular from extracellular signals [ 70] and is complexed to prevent toxicity.

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