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The first group contains short toxins (30-40 amino acid residues) with 3-4 disulfide bridges which mainly affect the voltage dependent K +channels and the large conductance calcium activated K +channels [ 5 6 ] .

The few studies documented on Buthus tamulus are restricted to the isolation and purification of neurotoxins, protease inhibitors, histamine releasers [ 19 ] iberiotoxin, an inhibitor of high conductance Ca 2+-activated K +channel [ 21 ] and neurotoxin Bt-II [ 20 ] .

In contrast to the non-NMDA receptors, the high conductance channel associated with the NMDA receptors is permeable to Ca 2+as well as to Na +and K +.

Since the amplitude and open channel noise of the different open levels are essentially the same, the conductance properties appear identical.

The channel closing rate may be dependent on the conductance state of neighboring channels via ionic fluxes or by direct interactions.

This may be the case as GABA can increase intracellular proton levels by intensifying bicarbonate ion conductance through a GABA-gated channel [ 15 ] which may act as a "developmental handshake" and regulate neuronal differentiation [ 16 ] .

Secondly, muscimol might increase the chloride conductance independent of gap junctions, and might cause a decrease in the spread of depolarization.

In that study they could not clarify how the activation of a GABAA receptor and subsequent increase in chloride conductance impact gap junctions.

Reduced root hydraulic conductance occurs shortly after plants are transferred from warm to cooler temperatures.

Similarly, Malone [ 17 ] observed a decrease in hydraulic conductance of spring wheat roots within minutes after plants were transferred from 22 to 8°C.

We conclude that reduced foliage water content in northern selected HRWW genotypes during extended acclimation is not due to impairment of root hydraulic conductance as proposed by Limin and Fowler [ 15 ] .

Our results suggest that the reduction in foliage water content observed among the northern-selected genotypes is due to greater stomatal conductance at 2°C.

Thus, at an irradiance of 4 µmol m -2s -1during 2°C exposure, it is likely that reduction in foliage water content of northern HRWW cultivars is due to induced stomatal conductance resulting from blue light rather than from a photosynthetic response.

Grant Support Part of this work was supported by a VA Merit Review Grant Abbreviations IBAT: ileal bile acid transporter, CFTR: cystic fibrosis transmembrane conductance regulator.

COP appears to be a unique molecule associated with the plasma membrane and to have a fixed pore geometry and conductance for each vital dye examined.

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