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Sentences for "conformational "
The structure of this 67 kDa domain has been determined by X-ray crystallography to be torus-like, indicating the need for protein conformational change for strand passage to take place after DNA cleavage [ 4 ] .
Removal of negative supercoils from DNA by bacterial type IA topoisomerase involves the following steps: (1) binding of the enzyme to the junction of double-stranded and single-stranded DNA [ 8 ] , (2) cleavage of a single-strand of DNA near the junction with cleavage sequence preference of a cytosine in the -4 position to form the covalent intermediate [ 9 10 ] , (3) conformational change of the covalent enzyme-DNA complex to result in physical separation of the 5' phosphate covalently linked to the active tyrosine, and the 3' hydroxyl of the cleaved DNA, (4) passage of the complementary single strand through the break, (5) enzyme conformational change to bring the 5' phosphoryl end back into the proximity of the 3' hydroxyl group of the cleaved DNA, (6) religation of the phosphodiester bond.
After cleavage of the DNA gate strand which becomes covalently linked to Tyr319 on Top67 (step 2), protein conformational change involving both Top67 and the ZD domain increases the distance between the covalently bound 5' phosphate and non-covalently bound 3' hydroxyl of the cleaved DNA gate strand while the passing DNA strand (T-strand) is guided through the "gate" via interaction with the ZD domain (step 3) to lead to change in linking number.
A second enzyme conformational change positions the cleaved DNA ends for religation (step 4).
To gain further details for this model of enzyme action, we are characterizing the protein-protein interactions between the Top67 transesterification domain and the ZD domain, as well as the protein conformational changes that can take place when the enzyme interacts with DNA substrate.
This is less likely to be the case with agonists since they must produce a conformational change in the protein to exert their effects.
The link between an agonist binding domain and a conformational change leading to channel opening is not unexpected since the two must obviously be linked.
Changes in fluorescence intensity during manipulation of a single parameter, like Ca 2+concentration, should report conformational changes in Alexa-calmodulin.
Thus, when Alexa-calmodulin was bound to IQ peptides, Ca 2+induced a conformational change that was substantially different from that seen in the peptide-free state.
In support of this view, we observed evidence for Ca 2+-dependent conformational changes in calmodulin while bound to IQ peptides.
Although the Ca 2+-induced conformational change could be a property of Alexa-calmodulin rather than calmodulin itself, the Ca 2+-dependent changes in affinity of calmodulin for IQ1 and IQ2 (Table 2) and calmodulin's likely shift to a new binding site on IQ3 suggests that the conformational change is probably also a property of authentic calmodulin.
, by inducing a conformational change in PEDF, which might accelerate the ligand-receptor interactions.
[ 18 ] In this study, By producing wtPAI-1 and several single site mutations in the distal hinge of PAI-1 in a baculovirus expression system, we were able to find out the role of the distal hinge in conformational transition of PAI-1 and to elucidate the role of Glu351 in PAI-1 for serine protease specificities.
The result of functional stability suggests that Glu351 is indeed involved in the conformational transition of PAI-1.
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