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Sentences for "contralateral "
In control embryos (n = 10) receiving a PB coated bead, GnRH neurons in each compartment were counted on the side ipsilateral and contralateral to the bead.
In PN-1 treated embryos, the distribution of GnRH neurons within the olfactory epithelium, nerve and brain on the side contralateral to the bead and that of controls were not significantly different indicating that the contralateral side in experimental embryos served as an internal control.
GnRH neuronal distribution ipsilateral to the bead was compared to that contralateral to the bead).
the side containing the bead and the contralateral side).
The contralateral side served as a within animal control.
For a subset of genes enriched in the dorsal spinal cord, we used QRT-PCR to compare the gene expression in the lumbar spinal cord between spinal nerve ligation rats and rats subjected to sham surgery, and to compare expression between ipsilateral and contralateral sides (separated by cutting through the midline in the segment of lumbar spinal cord) in spinal nerve ligation rats.
Similarly, expression between ipsilateral and contralateral samples were analyzed.
A similar contralateral effect has been observed with adenoviral-mediated delivery of viral (v)-IL-10.
Reduction in disease severity in noninjected front paws by local injection of IL-4 Previously, we have noted a contralateral effect, in which treatment of a diseased joint by adenovirus-mediated transfer of the gene that encodes v-IL-10 resulted in a therapeutic effect in noninjected joints.
To determine whether Ad-mIL-4 was able to confer a contralateral effect, the severity of disease in the hind and front paws of the mice injected only in the hind ankle joints was evaluated.
However, unlike v-IL-10, IL-4 is able to confer a contralateral therapeutic effect in mice with established disease.
Similarly, administration of v-IL-10 into one knee of rabbits with antigen-induced arthritis was able to confer a therapeutic effect in the contralateral untreated knee.
This observed contralateral effect was not limited to v-IL-10, in that coadministration of adenoviral vectors expressing soluble IL-1 and soluble TNF receptors also conferred a similar protective effect to untreated knees.
Although the mechanism of the contralateral effect is unclear, we have demonstrated that adoptive transfer of dendritic cells from animals treated with adenovirus-mediated gene transfer of v-IL-10 to untreated immunized animals is able to confer a therapeutic effect (unpublished data).
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