Use corticosterone in a sentence - Example Sentences for corticosterone
Obesity in several rodent models is also associated with elevated corticosterone levels, and adrenalectomy reverses some of the phenotypes associated with these forms of obesity [ 3 4 5 6 7 ] .
Furthermore, elevated corticosterone production can cause a metabolic syndrome [ 8 ] .
The high fat diet had no effect on serum corticosterone, but as expected adrenalectomy reduced serum corticosterone by over 70% in mice on both diets (Table I).
While this effect was significant, consistent with previous studies [ 6 ] , adrenalectomy did not eliminate detectable corticosterone completely.
Together with the reduction in serum corticosterone, this induction of pituitary POMC indicates that the adrenalectomy produced a physiologically significant reduction in corticosterone tone.
Since adrenalectomy only reduced plasma corticosterone by about 70% in the obese mice, rather than completely eliminating the steroid from circulation, it remains possible that even further reduction of corticosterone would produce an effect on diet-induced obese phenotypes.
On the other hand, using the same adrenalectomy protocol that produced a similar reduction, but not elimination, of plasma corticosterone levels, we observed a remarkable reversal of obese phenotypes in leptin-deficient ob/ob mice [ 6 ] .
Furthermore, the reduction of corticosterone by adrenalectomy in the present study was sufficient to produce elevation of pituitary POMC mRNA (as well as hypothalamic POMC mRNA), demonstrating that the reduced levels were clearly producing physiological effects.
The mice were sacrificed toward the end of the light period at the end of the day in the metabolic cages (between 17:00 and 19:00 h) by decapitation after a brief exposure to carbon dioxide and trunk blood was collected, we have verified in pilot studies that this method of sacrifice does not increase plasma corticosterone above levels observed without carbon dioxide exposure.
Successful adrenalectomy was verified by visual inspection at the time of sacrifice, as well as by the induction of pituitary proopiomelanocortin (POMC) mRNA levels and the reduction in serum corticosterone levels.
, Chicago, IL) and serum corticosterone was assayed by RIA with a commercial kit (ICN Pharmaceuticals Inc.
On the other hand, it has been reported that elevation of plasma corticosterone levels is not required for the induction of NPY mRNA by fasting [ 15 ] .
Therefore in the present study we assessed if an elevation of plasma corticosterone is necessary and sufficient to mediate effects of fasting and insulin deficiency on hypothalamic melanocortin tone, as indicated by expression of hypothalamic AGRP and POMC mRNA.
Serum corticosterone concentration increased with fasting as expected in the sham-operated mice (Fig.
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The word corticosterone
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