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Use corticotropin in a sentence - Example Sentences for corticotropin

The authors of the Science paper--"Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal"--suggest in their conclusion that marijuana may be as addictive as heroin and cocaine, and that pot's "subtle disruption" of brain chemistry may leave users " 'primed' for further disruption by other drugs of abuse.

LIF works in synergy with corticotropin-releasing hormone (CRH) in the hypothalamus to increase pituitary pro-opiomelanocortin (POMC) and, ultimately, pituitary adrenocorticotrophin hormone (ACTH) [ 9 11 13 14 15 16 ] .

Basal and corticotropin (ACTH)-stimulated cortisol levels correlate with the severity of illness, and very high cortisol levels often signify a poor prognosis [ 14].

Abbreviations AI = adrenal insufficiency, APACHE = Acute Physiology and Chronic Health Evaluation, ACTH = corticotropin, CI = confidence interval, OR = odds ratio, SOFA = Sequential Organ Failure Assessment.

Application to abolition of CRH-RI function data In this experiment, mRNAs from whole brains of mice of different genetic backgrounds which had been treated with an antagonist directed against the ligand-binding domain of a seven-transmembrane neuropeptide receptor [ 26] (the corticotropin-releasing hormone receptor 1 (CRH-R1) [ 27]) were compared to mRNAs from brains of mice lacking a functional CRH-R1 (CRH-R1 knockout mice [ 28]) using cDNA-microarrays (Table 1).

Mice with homozygous disruptions in the corticotropin-releasing hormone gene (see below) die at birth due to pulmonary immaturity.

The portal system carries the CRH to the anterior pituitary of the pituitary gland, where it stimulates corticotropes to secrete corticotropin (ACTH) and other biologically-active substances (for example ß-endorphin).

It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with corticotropin-releasing hormone from the hypothalamus).

"The hypothalamus secretes a number of releasing hormones, often according to a circadian rhythm, into hypophyseal portal system; most of these are stimulatory (thyrotropin-releasing hormone, corticotropin-releasing hormone, gonadotropin-releasing hormone and growth hormone-releasing hormone), apart from dopamine, which suppresses prolactin production."

Under certain conditions stress hormones may facilitate inflammation through induction of signaling pathways and through activation of the Corticotropin-releasing hormone.


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The word corticotropin


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