Use coupler in a sentence - Example Sentences for coupler
They clasped and sundered, did the coupler's will.
A signaling pathway coupler, or effector (in blue), is proposed to bind the activated state of Smo wtso as to generate a complex competent to initiate Hh signaling.
Throughout the discussion the term 'coupler/effector' is used to describe an unknown molecule that binds activated Smo in such a way as to trigger signal transduction.
The model further suggests that the Smo actprotein resides in a stable conformation in the absence of agonist that is capable of forming an active coupler/effector complex resistant to antagonist, but not agonist, binding.
Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo, secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state, and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
Two relatively novel concepts for Hh signaling are raised by these GPCR models: firstly, the importance of considering the active Smo-coupler/effector complexes when modeling pathway regulation, and secondly the potential for endogenous ligands in the regulation of Smo activity.
Thus, in considering models of Ptc function based on Hh-stimulated effects it is important to consider whether the form of Smo that is being observed is the active (coupler/effector bound) signaling state, or perhaps a downregulated and inactive form.
Several potential points for regulation by Ptc during the formation of a Smo-coupler/effector complex are apparent in a ternary complex model.
Ptc-induced instability of Smo protein would indirectly reduce the concentration of an active Smo-coupler/effector complex.
The uncertainty of the transmitting power measurement was less than ± 30%, and is basically composed of the uncertainty of the power measurement itself and the uncertainty of the direction coupler parameters.
MOTHER COUPLER, A Bawd.
You have weather'd many such a storm, Mother Coupler.
Where's Mother Coupler? Your honesty, Mother Coupler: We won't differ for a trifle.
Hah, Mother Coupler! Don't you and I know one another, Mother Coupler? Only first 17 results shown.
cousins in a sentence .. cowered in a sentence .. C
The word coupler
Example sentences with the coupler, a sentence example for coupler, and how to make coupler in sample sentence, Synonyms and Collocations for coupler how do I use the word coupler in a sentence? How do you spell coupler in a sentence? spelling of coupler
The word usage examples above have been gathered from various free and GNU sources to reflect current and historical usage. They do not represent the opinions of use-in-a-sentence.com.